The high toxicity of potent chemotherapeutic drugs limits the therapeutic window in which they can be applied. This window can be expanded by controlling the drug delivery in both space and time such that non-targeted tissues are not adversely affected. Our group is using ultrasound to control the release of anti-neoplastic agents from nanocarriers in both time and space. These nanovehicles include ligand-targeted polymeric micelles and liposomes. The potential benefits of such controlled chemotherapy compels a thorough investigation of role of ultrasound (US) and the mechanisms by which US accomplishes drug release and/or enhances drug potency which is the focus of our drug delivery group. Find out more.