Ghaleb A. Husseini, Assistant Professor
PhD Brigham Young University, USA 2001

Address:
Department of Chemical Engineering
College of Engineering
American University of Sharjah
P.O. Box 26666
Sharjah, United Arab Emirates

Room: EL 119
Office: +(971) 6 515 2970
Fax: +(971) 6 515 2979
E-mail: ghusseini@aus.edu

Research Interests

Polymeric drug delivery, surface modification, tissue culture, biomaterials, non-viral gene delivery and biomass analysis

Biography

Ghaleb Husseini has been an Assistant Professor of Chemical Engineering at the American University of Sharjah since January 2004. Dr. Husseini graduated with a PhD in Chemical Engineering (biomedical engineering emphasis) from Brigham Young University , Provo , UT , in August 2001. His PhD research involved sequestering chemotherapeutic agents (namely Doxorubicin and Ruboxyl) in stabilized Pluronic micelles. The contents of this drug delivery system can then be released using ultrasonic power. This way the drug has minimal interactions with the healthy cells in the host body, and it can carry out its therapeutic effect at the sonicated cancerous region only. In his project, he measured the release and re-encapsulation kinetics of several chemotherapy drugs from stabilized and unstabilized micelles. He also measured the amount of DNA damage induced by chemotherapeutic agents when delivered to human leukemia (HL-60) cells from Pluronic P105 micelles with and without the application of ultrasound. After graduation, he conducted research in the area of photochemical lithography and soft lithography. His projects aimed at creating acid chloride and epoxide functionalized surfaces by exposure to UV light. He also developed a novel method of micro-printing on silicon surfaces using scribed silicon wafers (soft lithography). He has started research in the area of non-viral gene delivery using ultrasonic power.

Selected Publications

Refereed Journal Articles

1. G. A. Husseini, R.I. El-Fayoumi, K.L. O'Neill, N.Y. Rapoport and W.G. Pitt, “DNA Damage Induced by Micellar-Delivered Doxorubicin and Ultrasound: Comet Assay Study.” Cancer Lett. 154, 211-216, 2000.
2. G.A. Husseini, G.D. Myrup, W.G. Pitt, D.A. Christensen and N.Y. Rapoport, “Factors Affecting Acoustically Triggered Release of Drugs from Polymeric Micelles.” Journal of Controlled Release. 69, 43-52, 2000.
3. J. Pruitt, G. Husseini, N. Rapoport and W. Pitt, “Stabilization of Pluronic P-105 Micelles with an Interpenetrating Network of N, N-diethylacrylamide,” Macromolecules. 33 (25), 9306-9309, 2000.
4. G. A. Husseini, N.Y. Rapoport, D.A. Christensen, J.D. Pruitt and W.G. Pitt, “Kinetics of Ultrasonic Release of Doxorubicin from Pluronic P105 Micelles.” Colloids and Surfaces B: Biointerfaces. 24 (3-4), 253-264, 2002.
5. M. Muniruzzaman, A. Marin, Y. Luo, G. Prestwich, W. Pitt, G. Husseini, N. Rapoport, “Intracellular uptake of Pluronic Copolymer: Effect of Aggregation State.” Colloids and Surfaces B: Biointerfaces, 25 (3), 233-241, 2002.
6. J. Hoggard , E.D. Carlson , S. H. Fredrickson , C. F. Monson , R. T. Bronson , P.B. Savage , M.R. Linford , G.A. Husseini. “Analysis of 7,13 bis((8 hydroxy 2 –quin -linyl) methyl) 1,4 dimethyl 1,4,7,13 Tetraaza-10 thiacyclopentadecane by XPS." Surface Science Spectra, 9, 227-233, 2002.
7. N. Radicic, H. Becerril-Garcia, A. Myrer, E. Cory, R. T. Bronson, P.B. Savage, M.R. Linford, G.A. Husseini. “ Analysis of 10,16-Diaza-1,4,7,13-tetrathiacyclooctane-9,17-dione by XPS." Surface Science Spectra, 9, 234-240, 2002.
8. J. Thomson, J. Stoker, J. Bunker, N. Agbonkonkon, R. T. Bronson, P.B. Savage, M.R. Linford, G.A. Husseini. “Analysis of 5-chloro-8-methoxy-2-(bromomethyl)quinoline by XPS.” Surface Science Spectra, 9, 241-249, 2002.
9. G. A. Husseini, C. Runyan, W.G. Pitt. “Investigating the Mechanism of Acoustically Activated Uptake of Drugs from Pluronic Micelles.” BioMed Central, 2, art. 20, 2002.
10. G. A. Husseini, D.A. Christensen, N.Y. Rapoport, W.G. Pitt, “Ultrasonic Release of Doxorubicin from Pluronic Micelles Stabilized with an Interpenetrating Network of N, N-diethylacrylamide.” Journal of Controlled Release, 83, 303-305, 2002.
11. G. A. Husseini, A. Marin, H. Sun, D.A. Christensen, W.G. Pitt, N.Y. Rapoport, “Drug Delivery in Pluronic Micelles: Effect of High-Frequency Ultrasound on Drug Release from Micelles and Intracellular Uptake.” Journal of Controlled Release, 84, 39-47, 2002.
12. G. A. Husseini, T.L. Niederhauser, J.G. Peacock, M.R. Vernon, Y.-Y. Lua, M.C. Asplund, E.T. Sevy, M.R. Linford, “Photochemical Lithography: Creation of Patterned Acid Chloride Functionalized Surfaces Using UV Light and Gas-Phase Oxalyl Chloride.” Langmuir, 19, 4856-4858, 2002.
13. G. A. Husseini, J.G. Peacock, A. Sathyapalan, L.W. Zilch, M.C. Asplund, E.T. Sevy, M.R. Linford, “Alkyl Monolayers on Silica Surfaces Prepared Using Neat, Heat Dimethylmonochlorosilanes with Low Vapor Pressures.” Langmuir, 19, 5169-5171, 2003.
14. J. Whittaker, M. Brink, G. Husseini., M.R. Linford, R.C. Davis. “Self-Aligned Mechanical Attachment of Carbon Nanotubes to Silicon Dioxide Structures by Selective Silicon Dioxide Chemical Vapor Deposition.” Applied Physics Letters, 83, 5307-5309, 2003.
15. G.A. Husseini, J. Peacock, E. Sevy, M.C. Asplund, M. R. Linford, “XPS of Alkyl Monolayers on Silica Surfaces Prepared from Neat, Heated (Tridecafluoro-1,1,2,2-tetrahydroocytyl)-1-dimethylchlorosilane under Ambient Conditions.” Surface Science Spectra, 9, 260-265, 2004.
16. Zilch, L.W., G.A. Husseini, Y.Y. Lua, M.V. Lee, K.R. Gertsch, B.R. Cannon, R.M. Perry, E.T. Sevy, M.C. Asplund, A.T. Woolley, M.R. Linford. “Rapid and Convenient Method for Preparing Masters for Microcontact Printing with 1-12 mm Features.” Review of Scientific Instruments, 75, 3065-3067, 2004.
17. G. Jiang, G. A. Husseini, L. L. Baxter , M. R. Linford, “Analysis of Straw by X-ray Photoelectron Spectroscopy.” Surface Science Spectra, 11, 91-96, 2004.
18. W.G. Pitt , G.A. Husseini , B.J. Staples. “Ultrasonic Drug Delivery-A General Review.” Expert Opinions in Drug Delivery, 1 (1), 37-56, 2004.
19. R.T. Bronson, D.J. Michaelis, R.D Lamb, G.A. Husseini, P.B. Farnsorth, M.R. Linford, R.M. Izatt, J.S. Bradshaw, P.B. Savage. “Efficient immobilization of a cadmium chemosensor in a thin film: generation of a cadmium sensor prototype.” Organic Letters, 7(6) p. 1105-1108, 2005.
20. G.A. Husseini , M.A. De La Rosa , E. Richardson , D.A. Christensen, W.G. Pitt. “The Role of Cavitation in Acoustically Activated Drug Delivery.” Journal of Controlled Release, 107(2), 253-261, 2005.
21. G.A. Husseini , K.L. O’Neill , W.G. Pitt. “Mode of Cell Death for the Ultrasonic Delivery of Doxorubicin to Human Leukemia (HL-60 cells) from Pluronic P105 Micelles.” Technol Cancer Res Treat, 4(2) 707-712 2005.

Conference Papers

1. G. Husseini, D.A. Christensen, W.G. Pitt and N. Rapoport. “Acoustically Activated Delivery of Doxorubicin and Ruboxyl to HL-60 Cells from Pluronic (P-105) Micelles: A Real Time Measurement.” Twenty-Fifth Annual Meeting of the Society for Biomaterials. Providence, RI, USA: Society for Biomaterials, 1999.
2. G.A. Husseini, W.G. Pitt, R.Y.A. Fayoumi, K.L. O'Neill and N.Y. Rapoport. “Acoustically Activated Delivery of Doxorubicin to HL-60 Cells from Pluronic (P-105) Micelles: A Single Cell Electrophoresis Assay (Comet Assay) Study.” AICHE Annual Meeting. Dallas, TX, USA: American Institute of Chemical Engineers, 1999.
3. G.A. Husseini., W.G. Pitt, D.A. Christensen and N.Y. Rapoport. “Acoustically Activated Doxorubicin Release from Pluronic P105 Micelles.” AICHE Annual Meeting. Los Angeles, CA, USA: American Institute of Chemical Engineers, 2000.
4. W.G. Pitt, G. A. Husseini, N. Rapoport, D.A. Christensen and R. Al-Fayoumi. “Ultrasonic-Activated Pluronic Micelles for Controlled Drug Delivery.” Sixth World Biomaterials Congress. Kamuela, HI, USA: Society of Biomaterials, 2000.
5. N.Y. Rapoport, W.G. Pitt, D.A. Christensen, G. A. Husseini. “Factors Affecting Controlled Release of Drugs from Polymeric Micelle.” Proceedings of the International Symposium of Controlled Release Bioactive Materials. Paris, France, 2000.
6. G. A. Husseini, W.G. Pitt, J. Pruitt, N. Rapoport. “Ultrasonically Controlled Release of Doxorubicin from Pluronic Micelles.” Twenty-Seventh Annual Meeting of the Society for Biomaterials. St. Paul, MN, USA: Society for Biomaterials, 2001.
7. W.G. Pitt, G.A. Husseini, N. Rapoport and D.A. Christensen. “Ultrasonically Activated Drug Delivery Vehicles.” AICHE Annual Meeting. Indianapolis, IN, USA: American Institute of Chemical Engineers, 2002.
8. W.G. Pitt, N. Rapoport, B.L. Roeder, J.L. Nelson, J. Pruitt, D.A. Christensen, G.A. Husseini, A.L. Nelson, K. Potter. “Stabilized Micelles for Use in Ultrasonically Activated Chemotherapy.” Twenty-Eighth Annual Meeting of the Society for Biomaterials. Tampa, FL, USA: Society for Biomaterials, 2002.
9. G.A. Husseini E.T. Sevy, M.C. Asplund, M.R. Linford. “Functionalization and Patterning of C-H Containing Surfaces Using Oxalyl Chloride.” Forty-ninth International Symposium of AVS. Denver, CO, USA: American Vacuum Society, 2002.
10. M.C. Asplund, G.A. Husseini, M.R. Linford, E.T. Sevy. “Formation of Chemically Patterned Surfaces Using Gas-Phase Oxalyl Chloride.” Forty-ninth International Symposium of AVS. Denver, CO, USA: American Vacuum Society, 2002.
11. L.W. Zilch, G. A. Husseini, Y.Y. Lau, A.T. Woolley, E.T. Sevy, M.C. Asplund, M.R. Linford. “Non-Photolithographic Non-Clean Room Micropatterning of Surfaces.” Forty-ninth International Symposium of AVS, Denver, CO, USA: American Vacuum Society, 2002.
12. G.A. Husseini, S. Dabell, C. Crofts, B. Nelson, J. Cameron , H. Vollmer-Snarr. “A2E Mechanism of Action and Targeted Drug Delivery.” In National Chemistry Week- Central Utah Section, Provo, UT, USA : American Chemical Society, 2005.
13. G. Husseini , M., De la Rosa, D.A. Christensen, W.G. Pitt. “The Role of Cavitation in Ultrasonic Release of Doxoribicin from Pluronic (P-105) Micelles.”In Thirty-First Annual Meeting of the Society For Biomaterials . Memphis, Tennessee, USA : Society For Biomaterials, 2005.
14. G.A. Husseini , M. A. Diaz de la Rosa, T. Gabuji, D.A. Christensen, W.G. Pitt . “Acoustically Activated Release of Doxorubicin from Unstabilized and Stabilized Micelles.” In Thirty-Second Annual Meeting For the Controlled Release Society. Miami, FL, USA: Controlled Release Society, 2005.
15. G. Husseini, “Modeling Acoustic Release of Doxorubicin From Pluronic P105 Micelles Stabilized Using An interpenetrating Network of N, N-Diethylacrylamide.” In the First International Conference On Modeling, Simulation and Applied Optimization. Sharjah, United Arab Emirates, 2005.
16. G.A. Husseini, E. AlAqqad, S. Al Mamary, Y. Kadimati, A. Al Baik, M. Diaz de la Rosa, W. G. Pitt, Kinetics of Acoustic Release of Doxorubicin from Stabilized and Unstabilized Micelles and the Effect of Temperature. In The Third International Symposium on Mechatronics at the American University of Sharjah (ISM06-AUS). Sharjah, UAE, 2006.
17. H. Al-Nashash, N. Qaddoumi, G. Al-Husseini. “Biomedical Electronics Education at the American University of Sharjah.” In International Medical Informatics and Biomedical Engineering Symopsium (IMIBE’06). Amman, Jordan, 2006.